![]() Genetic trajectories, by repeatedly acquiring the same 21-bp consensus motifįor recruitment of the dosage compensation complex, yet utilizing a diverseĪrray of random mutational changes to attain the same phenotypic outcome. Our study also highlights how evolution can follow predictable Our findings have broad implications for current models of sex chromosomeĮvolution, and demonstrate how mechanistic constraints can limit evolutionaryĪdaptations. Neo-Y show little overlap, possibly reflecting different propensities along theĪncestral chromosome to adopt active or repressive chromatin configurations. Intriguingly, the genomic regions being targeted by the dosageĬompensation complex on the neo-X and those becoming heterochromatic on the Mis-expression of neo-sex linked genes, and little correspondence betweenįunctionality of genes and their silencing on the neo-Y or dosage compensation Spreading of these silencing orĪctivating chromatin modifications to adjacent regions results in massive Or tandem amplification of weak binding sites. Pre-binding sites, insertion and deletion mutations, microsatellite expansions, Utilized to establish several dozen novel binding consensus motifs for theĭosage compensation complex on the neo-X, including simple point mutations at With keyboard shortcuts that keep your fingers close to the home row you can transcribe on any Windows or. The neo-X has evolved partialĭosage compensation and we find that diverse mutational paths have been HyperTRANSCRIBE lets you transcribe nearly any audio or video file, quickly and easily. When you come to the starting point of a segment you want to code, press Control- (if you use Windows) or Command- (if you use Mac OS X). Triggered by an accumulation of repetitive DNA. We show that the onset of heterochromatin formation on the neo-Y is Mechanisms and functional pressures driving heterochromatin formation andĭosage compensation of the recently formed neo-sex chromosomes of Drosophila Hypertranscribed due to dosage compensation. ![]() ![]() While male X chromosomes have highly accessible chromatin and are Download a PDF of the paper titled The epigenome of evolving Drosophila neo-sex chromosomes: dosage compensation and heterochromatin formation, by Qi Zhou and 5 other authors Download PDF Abstract: Drosophila Y chromosomes are composed entirely of silent heterochromatin, ![]()
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